University of Geneva, University Clinics of Dental Medicine 1 article published in JoVE Bioengineering Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials Laurine Marger1, Antonio Barone2, Carla P. Martinelli-Kläy3, Leandra Schaub1, Malin Strasding4, Mustapha Mekki1, Irena Sailer4, Susanne S Scherrer1, Stéphane Durual1 1Division of Fixed Prosthodontics and Biomaterials, Biomaterials Laboratory, University of Geneva, University Clinic of Dental Medicine, 2Department of Surgery, Division of Oral and Maxillofacial Surgery (HUG), Unity of Oral Surgery and Implantology, University of Geneva, University Clinic of Dental Medicine, 3Department of Surgery, Division of Oral and Maxillofacial surgery (HUG), Laboratory of Oral & Maxillofacial Pathology, University of Geneva, University Clinic of Dental Medicine, 4Division of Fixed Prosthodontics and Biomaterials, University of Geneva, University Clinic of Dental Medicine Here we present a surgical protocol in rabbits with the aim to assess bone substitution materials in terms of bone regeneration capacities. By using PEEK cylinders fixed onto rabbit skulls, osteoconduction, osteoinduction, osteogenesis and vasculogenesis induced by the materials may be evaluated either on live or euthanized animals.
