AO Research Institute Davos 1 article published in JoVE Medicine A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease. Babak Saravi*1,2, Gernot Lang*2, Sibylle Grad1, Mauro Alini1, R. Geoff Richards1,2, Hagen Schmal2, Norbert Südkamp2, Zhen Li1 1AO Research Institute Davos, Davos, Switzerland, 2Department of Orthopedics and Trauma Surgery, Medical Centre-Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany This protocol presents a novel experimental model of proinflammatory, degenerative bovine organ culture to simulate early-stage intervertebral disc degeneration.
