Cyprus Institute of Neurology and Genetics 1 article published in JoVE Bioengineering Equipment Setup and Artifact Removal for Simultaneous Electroencephalogram and Functional Magnetic Resonance Imaging for Clinical Review in Epilepsy Jihye Bae1, Jordan L. Clay2, Bhoj Raj Thapa1, David Powell3, Heidi Turpin3, Saghi Tasori Partovi3, Rachel Ward-Mitchell3, Balu Krishnan4, Andreas Koupparis5, Meriem Bensalem Owen2, Flavius D. Raslau2,6,7 1Department of Electrical and Computer Engineering, University of Kentucky, 2Department of Neurology, University of Kentucky, 3Department of Neuroscience, University of Kentucky, 4Cleveland Clinic, 5Cyprus Institute of Neurology and Genetics, 6Department of Radiology, University of Kentucky, 7Department of Neurosurgery, University of Kentucky This article details simultaneous electroencephalogram and functional magnetic resonance imaging (EEG-fMRI) recording procedures that can be used in both clinical and research settings. EEG processing procedures to remove imaging artifacts for clinical review are also included. This study focuses on the example of epilepsy during the interictal period.