Academy of Science of the Czech Republic 1 article published in JoVE Medicine Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow Antonia Link1, Giorgio Cattaneo2,3, Eduard Brynda4, Tomas Riedel4, Johanka Kucerova4, Christian Schlensak1, Hans Peter Wendel1, Stefanie Krajewski1, Tatjana Michel1 1Department of Thoracic, Cardiac and Vascular Surgery, University Hospital Tuebingen, 2Acandis GmbH, 3Institute of Biomedical Engineering, University of Stuttgart, 4Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic This protocol describes a comprehensive hemocompatibility evaluation of blood-contacting devices using laser-cut neurovascular implants. A flow loop model with fresh, heparinized human blood is applied to mimic blood flow. After perfusion, various hematologic markers are analyzed and compared to the values gained directly after blood collection for hemocompatibility evaluation of the tested devices.
