Federal Institute for Drugs and Medical Devices 3 articles published in JoVE Neuroscience Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice Andreas Lundt1,2, Julien Soos1, Christina Henseler1, Muhammad Imran Arshaad1, Ralf Müller3, Dan Ehninger4, Jürgen Hescheler5, Agapios Sachinidis5, Karl Broich6, Carola Wormuth1,7, Anna Papazoglou1, Marco Weiergräber1 1Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 2KBRwyle GmbH, 3Cognitive Neurophysiology, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Cologne, 4Molecular and Cellular Cognition, German Center for Neurodegenerative Diseases (DZNE), 5Institute of Neurophysiology, Faculty of Medicine, University of Cologne, 6Federal Institute for Drugs and Medical Devices (BfArM), 7Thescon GmbH Brainstem evoked response audiometry is an important tool in clinical neurophysiology. Nowadays, brainstem evoked response audiometry is also applied in the basic science and preclinical studies involving both pharmacological and genetic animal models. Here we provide a detailed description of how auditory brainstem responses can be successfully recorded and analyzed in mice. Behavior Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG Ralf Müller1, Anna Papazoglou2, Julien Soos2, Andreas Lundt2, Carola Wormuth2, Christina Henseler2, Dan Ehninger3, Karl Broich4, Marco Weiergräber2 1Department of Psychiatry and Psychotherapy, University of Cologne, 2Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 3Molecular and Cellular Cognition Lab, German Center for Neurodegenerative Diseases, 4Federal Institute for Drugs and Medical Devices Theta activity in the hippocampus is related to specific cognitive and behavioral stages. Here, we describe an analytical method to detect highly-organized theta oscillations within the hippocampus using a time-frequency (i.e., wavelet analysis)-based approach. Neuroscience Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement Anna Papazoglou1, Andreas Lundt1, Carola Wormuth1, Dan Ehninger2, Christina Henseler1, Julien Soós1, Karl Broich1, Marco Weiergräber1 1Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), 2Molecular and Cellular Cognition Lab, German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen, DZNE) Non-restraining EEG radiotelemetry is a valuable methodological approach to record in vivo long-term electroencephalograms from freely moving rodents. This detailed protocol describes stereotaxic epidural and deep intracerebral electrode placement in different brain regions in order to obtain reliable recordings of CNS rhythmicity and CNS related behavioral stages.
