GE Global Research 1 article published in JoVE Cancer Research Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging Eugen Kubala*1,2,3, Kim A. Muñoz-Álvarez*1, Geoffrey Topping1, Christian Hundshammer1,2, Benedikt Feuerecker1, Pedro A. Gómez3,4, Giorgio Pariani1,5,6, Franz Schilling1, Steffen J. Glaser2, Rolf F. Schulte3, Marion I. Menzel3, Markus Schwaiger1 1Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, 2Department of Chemistry, Technische Universität München, 3GE Global Research, 4Zentralinstitut für Medizintechnik der Technischen Universität München (IMETUM), Technische Universität München, 5Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, 6IDG Institute of Developmental Genetics, Helmholtz Zentrum München Dynamic nuclear polarization with subsequent sample dissolution has enabled real-time studies of metabolism in biological systems. Hyperpolarized [1-13C]pyruvate was used to study lactate dehydrogenase activity in a prostate carcinoma cell line in vitro.
