PALGA foundation, The nationwide network and registry of histo- and cytopathology 1 article published in JoVE Medicine Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way Yassine Aaboubout1,2, Elisa M. Barroso1,3,4, Mahesh Algoe1, Patricia C. Ewing-Graham1, Ivo ten Hove3,6, Hetty Mast3, José A. Hardillo2, Aniel Sewnaik2, Dominiek A. Monserez2, Stijn Keereweer2, Brend P. Jonker3, Cornelia G. F. van Lanschot2, Roeland W. H. Smits2, Maria R. Nunes Soares1,4, Lars Ottevanger1, Sanne E. Matlung1, Paul A. Seegers5, Vera van Dis1, Robert M. Verdijk1, Eppo B. Wolvius3, Peter J. Caspers4, Tom C. Bakker Schut4, Robert J. Baatenburg de Jong2, Gerwin J. Puppels4, Senada Koljenović1 1Department of Pathology, Erasmus MC University Medical Center, 2Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC University Medical Center, 3Department of Oral and Maxillofacial Surgery, Erasmus MC University Medical Center, 4Department of Dermatology, Erasmus MC University Medical Center, 5PALGA foundation, The nationwide network and registry of histo- and cytopathology, 6Department of Oral and Maxillofacial Surgery, Leiden University Medical Center The goal of this protocol is to provide a clear overview of specimen-driven intraoperative assessment of resection margins. It is encouraged to implement this protocol to improve patient care at other institutes.