Nencki Institute of Experimental Biology of Polish Academy of Sciences 1 article published in JoVE Neuroscience Serial Block-Face Scanning Electron Microscopy (SBEM) for the Study of Dendritic Spines Małgorzata A. Śliwińska1, Anna Cały2, Jędrzej Szymański1, Kasia Radwańska2 1Laboratory of Imaging Tissue Structure and Function, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 2Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences Serial Block-Face Scanning Electron Microscopy (SBEM) is applied to image and analyze dendritic spines in the murine hippocampus.