Serbian Academy of Science and Arts 1 article published in JoVE Bioengineering In Silico Clinical Trials for Cardiovascular Disease Nenad Filipovic1,2, Igor Saveljic2,3, Tijana Sustersic1,2, Miljan Milosevic2,3, Bogdan Milicevic1,2, Vladimir Simic2,3, Milos Ivanovic1,4, Milos Kojic1,5 1Bioengineering Research and Development Center BioIRC, 2Faculty of Engineering, University of Kragujevac, 3Institute for Information Technology, University of Kragujevac, 4Faculty of Science, University of Kragujevac, 5Serbian Academy of Science and Arts This protocol demonstrates the workflow of the SILICOFCM platform for automatically generating a parametric model of the left ventricle from patient-specific ultrasound images by applying a multi-scale electromechanical model of the heart. This platform enables in silico clinical trials intended to reduce real clinical trials and maximize positive therapeutic outcomes.
