Fraunhofer IWS 1 article published in JoVE Bioengineering The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture Eva-Maria Materne*1, Ilka Maschmeyer*1,2, Alexandra K. Lorenz1, Reyk Horland1,2, Katharina M. S. Schimek1, Mathias Busek3, Frank Sonntag3, Roland Lauster1, Uwe Marx1,2 1Medical Biotechnology, Technische Universität Berlin, 2TissUse GmbH, 3Fraunhofer IWS Here, we present a protocol to coculture primary cells, tissue models and punch biopsies in a microfluidic multi-organ chip for up to 28 days. Human dermal microvascular endothelial cells, liver aggregates and skin biopsies were successfully combined in a common media circulation.
