National Hospital for Neurology and Neurosurgery 3 articles published in JoVE Bioengineering Patient-Specific Polyvinyl Alcohol Phantom Fabrication with Ultrasound and X-Ray Contrast for Brain Tumor Surgery Planning Eleanor C. Mackle*1,2, Jonathan Shapey*1,2,3,4, Efthymios Maneas1,2, Shakeel R. Saeed3,5,6, Robert Bradford3, Sebastien Ourselin4, Tom Vercauteren4, Adrien E. Desjardins1,2 1Wellcome / EPSRC Centre for Interventional and Surgical Sciences, University College London, 2Department of Medical Physics and Biomedical Engineering, University College London, 3Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, 4 This protocol describes the fabrication of a patient specific skull, brain and tumor phantom. It uses 3D printing to create molds, and polyvinyl alcohol (PVA-c) is used as the tissue mimicking material. Neuroscience Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties Agnes Witt1, Hugh Bostock2, Werner J. Z'Graggen3, S. Veronica Tan4, Alexander Gramm Kristensen1, Rikke Søgaard Kristensen1, Lotte Hardbo Larsen1, Zennia Zeppelin1, Hatice Tankisi1 1Department of Clinical Neurophysiology, Aarhus University Hospital, 2UCL Queen Square Institute of Neurology, Queen Square House, 3Departments of Neurology and Neurosurgery, Inselspital, Bern University Hospital, University of Bern, 4MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery Presented here is a protocol for the recording of muscle velocity recovery cycles (MVRCs), a new method of examining muscle membrane properties. MVRCs enable in vivo assessment of muscle membrane potential and alterations in muscle ion channel function in relation to pathology, and it enables the demonstration of muscle depolarization in neurogenic muscles. Medicine A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery Mark Nowell1, Roman Rodionov1, Gergely Zombori2, Rachel Sparks2, Michele Rizzi1, Sebastien Ourselin2, Anna Miserocchi3, Andrew McEvoy3, John Duncan1 1Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, 2Center of Medical Imaging and Computing, UCL, 3Department of Neurosurgery, National Hospital for Neurology and Neurosurgery We describe the steps to use our custom designed software for image integration, visualization and planning in epilepsy surgery.
