University of Padua School of Medicine 1 article published in JoVE Biology De Novo Generation of Somatic Stem Cells by YAP/TAZ Tito Panciera1, Luca Azzolin1, Daniele Di Biagio1, Antonio Totaro1, Michelangelo Cordenonsi1, Stefano Piccolo1 1Department of Molecular Medicine, University of Padua School of Medicine Availability of somatic SCs is crucial for regenerative medicine, disease modeling and to gain insight into SC properties. Here we present experimental strategies to reprogram, in vitro, differentiated adult cells into their corresponding expandable tissue-specific stem/progenitor cells by the transient expression of the single transcriptional co-activator YAP.
