Fondazione IRCCS Ca Granda, Ospedale Policlinico di Milano 1 article published in JoVE Immunology and Infection Using Robotic Systems to Process and Embed Colonic Murine Samples for Histological Analyses Fulvia Milena Cribiù*1, Claudia Burrello*2, Roberta Tacchi1, Francesca Boggio1, Dario Ricca1, Flavio Caprioli3,4, Stefano Ferrero1, Federica Facciotti2 1Pathology Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, 2Department of Experimental Oncology, European Institute of Oncology, 3 Lack of standardization for murine tissue processing reduces the quality of murine histopathological analysis as compared to human specimens. Here, we present a protocol to perform histopathological examination of murine inflamed and uninflamed colonic tissues to show the feasibility of robotic systems routinely used for processing and embedding human samples.
