International School for Advanced Studies View Institution's Website 1 article published in JoVE Neuroscience Flash Photolysis of Caged Compounds in the Cilia of Olfactory Sensory Neurons Anna Boccaccio1,2, Claudia Sagheddu1, Anna Menini1,3 1SISSA, International School for Advanced Studies, 2Istituto di Biofisica, Consiglio Nazionale delle Ricerche, 3SISSA Unit, Italian Institute of Technology Photolysis of caged compounds allows the production of rapid and localized increases in the concentration of various physiologically active compounds. Here, we show how to obtain patch-clamp recordings combined with photolysis of caged cAMP or caged Ca for the study of olfactory transduction in dissociated mouse olfactory sensory neurons.