The Johns Hopkins Medical Institutions 1 article published in JoVE Biology A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models Genri Numata1,2, Eiki Takimoto1,3 1Department of Cardiovascular Medicine, The University of Tokyo Hospital, 2Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, The University of Tokyo, 3Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions The present protocol describes obtaining the pressure-volume relationship through transesophageal pacing, which serves as a valuable tool in evaluating diastolic function in mouse models of heart failure.
