Siena College 1 article published in JoVE Chemistry Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile Andrew B. Lutjen1, Mackenzie A. Quirk1, Erin M. Kolonko1 1Department of Chemistry and Biochemistry, Siena College A modified Steglich esterification reaction was used to synthesize a small library of ester derivatives with primary and secondary alcohols. The methodology uses a non-halogenated and greener solvent, acetonitrile, and enables product isolation in high yields without the need for chromatographic purification.
