GE Global Research USA 1 article published in JoVE Bioengineering Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension Flemming Forsberg1, Ipshita Gupta1,2, Priscilla Machado1, Colette M. Shaw1, Jonathan M. Fenkel3, Kirk Wallace4, John R. Eisenbrey1 1Department of Radiology, Thomas Jefferson University, 2School of Biomedical Engineering, Sciences and Health Systems, Drexel University, 3Department of Medicine, Division of Gastroenterology and Hepatology, Thomas Jefferson University, 4GE Global Research A protocol for noninvasively estimating ambient pressures utilizing subharmonic ultrasound imaging of infused contrast microbubbles (following appropriate calibration) is described with examples from human patients with chronic liver disease.
