Geisinger Health System 1 article published in JoVE Medicine The Lower Body Positive Pressure Treadmill for Knee Osteoarthritis Rehabilitation Junjie Liang*1,2, Yuanyuan Guo*1,2, Yuxin Zheng1,2, Shijuan Lang1, Hongxin Chen1,2, Yaoyao You1,2, Bryan O’Young3,4, Haining Ou*1,2, Qiang Lin*1,2 1Department of Rehabilitation, The Fifth Affiliated Hospital of Guangzhou Medical University, 2Experiment Education Model Center of Rehabilitation Medicine, Guangzhou Medical University, 3Department of Physical Medicine and Rehabilitation, Geisinger Health System, 4Department of Rehabilitation Medicine, New York University School of Medicine Here, based on a clinician’s point-of-view, we propose a two-model lower body positive pressure (LBPP) protocol (walking and squatting models) in addition to a clinical, functional assessment methodology, including details for further encouragement of the development of non-drug surgical intervention strategies in knee osteoarthritis patients. However, we only present the effect of LBPP training in improvement of pain and knee function in one patient through three-dimensional gait analysis. The exact, long-term effects of this approach should be explored in future studies.