Kent Memorial Hospital 1 article published in JoVE Medicine Demonstration of the Rat Ischemic Skin Wound Model Andrea N. Trujillo*1, Shannon L. Kesl*1,2, Jacob Sherwood1, Mack Wu2, Lisa J. Gould1,3 1Department of Molecular Pharmacology and Physiology, University of South Florida, 2Department of Surgery, University of South Florida, 3Wound Recovery and Hyperbaric Medicine Center, Kent Memorial Hospital The rat, due to its size, availability, and rather docile behavior, has been utilized as a research model for many years. The goal of this protocol is to utilize the rat as an ischemic skin wound healing model to provide valuable insight into the pathophysiology of chronic wounds.