Children's Research Institute (CRI) 1 article published in JoVE Immunology and Infection Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice Dorothee Weihrauch1, John G. Krolikowski1,2, Deron W. Jones3, Tahniyath Zaman3, Omoshalewa Bamkole1, Janine Struve4, Paul S. Pagel5, Nicole L. Lohr6, Kirkwood A. Pritchard, Jr.3 1Department of Anesthesiology, Medical College of Wisconsin, 2Clement J. Zablocki Veterans Affairs Medical Center, 3 We describe the isolation of cardiac extracellular matrix from C57Bl/6J control mice, tight-skin mice, and tight-skin mice treated with the IRF5 inhibitory peptide. We also describe the vasodilation studies on the isolated vessels from C57Bl/6J, tight-skin mice and tight-skin mice treated with the IRF5 inhibitory peptide.
