University of Rochester School of Medicine and Dentistry 1 article published in JoVE Biology Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid Muhammad Ummear Raza1, Kavaljit H. Chhabra1 1Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Rochester School of Medicine and Dentistry This article describes a detailed protocol to increase glucose concentration in the cerebrospinal fluid (CSF) of mice. This approach can be useful for studying the effects of high CSF glucose on neurodegeneration, cognition, and peripheral glucose metabolism in mice.
