3 articles published in JoVE
Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions Robert W. Harkness V1, Philip E. Johnson2, Anthony K. Mittermaier1 1Department of Chemistry, McGill University, 2Department of Chemistry, York University We present a protocol for rapid characterization of biomolecular folding and binding interactions with thermolabile ligands using differential scanning calorimetry.
Time-resolved ElectroSpray Ionization Hydrogen-deuterium Exchange Mass Spectrometry for Studying Protein Structure and Dynamics Cristina Lento1, Shaolong Zhu1, Kerene A. Brown1, Ruth Knox1, Peter Liuni1, Derek J. Wilson1,2,3 1Department of Chemistry, York University, 2The Centre for Research in Mass Spectrometry, York University, 3The Centre for Research on Biomolecular Interactions, York University Conformational flexibility plays a critical role in protein function. Herein, we describe the use of time-resolved electrospray ionization mass spectrometry coupled to hydrogen-deuterium exchange for probing the rapid structural changes that drive function in ordered and disordered proteins.
Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis Joseph F.X. DeSouza1,2, Shima Ovaysikia1, Laura K. Pynn1 1Department of Psychology, Centre for Vision Research, York University, 2Department of Biology, Centre for Vision Research, York University The goal of our research is to correlate behavior to brain activity. Accurate behavioral measures and imaging techniques allow us to elucidate brain-behavior relationships.