2 articles published in JoVE
Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray Yvonne Linger1, Alexander Kukhtin1, Julia Golova1, Alexander Perov1, Peter Qu1, Christopher Knickerbocker1, Christopher G. Cooney1, Darrell P. Chandler1 1Akonni Biosystems, Inc. An amplification microarray combines asymmetric PCR amplification and microarray hybridization into a single chamber, which significantly streamlines microarray workflow for the end user. Simplifying microarray workflow is a necessary first step for creating microarray-based diagnostics that can be routinely used in lower-resource environments.
High-throughput, Automated Extraction of DNA and RNA from Clinical Samples using TruTip Technology on Common Liquid Handling Robots Rebecca C. Holmberg1, Alissa Gindlesperger1, Tinsley Stokes1, Dane Brady2, Nitu Thakore3, Philip Belgrader3, Christopher G. Cooney3, Darrell P. Chandler4 1Application Development, Akonni Biosystems, Inc., 2Manufacturing, Akonni Biosystems, Inc., 3Engineering, Akonni Biosystems, Inc., 4Research & Development, Akonni Biosystems, Inc. TruTip is a simple nucleic acid extraction technology whereby a porous, monolithic binding matrix is inserted into a pipette tip. Consequently, the sample preparation format is compatible with most liquid handling instruments, and can be used for many medium to high-throughput clinical applications and sample types.