Kansas City University of Medicine and Biosciences 1 article published in JoVE Neuroscience Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets Jessica M. Sage1, LaSharice Hall2, April McVey3, Richard J. Barohn3, Jeffrey M. Statland3, Omar Jawdat3, Mazen M. Dimachkie3, Abdulbaki Agbas1 1Department of Basic Sciences, Kansas City University of Medicine and Biosciences, 2Rice University School of Medicine, 3University of Kansas Medical Center Blood-based biomarkers for neurodegenerative diseases are essential for implementing large-scale clinical studies. A reliable and validated blood test should require a small sample volume as well as be a less invasive sampling method, affordable, and reproducible. This paper demonstrates that high-throughput capillary electrophoresis immunoassay satisfies criteria for potential biomarker development.
