3 articles published in JoVE
The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders Tuan D. Tran1,2, Aenia Amin1,2, Keith G. Jones2, Ellen M. Sheffer1, Lidia Ortega1, Keith Dolman2 1Department of Psychology, East Carolina University, 2Multidisciplinary Studies Program in Neuroscience, East Carolina University Trace eyeblink classical conditioning (ECC) was used to assess hippocampal-dependent associative learning in adult rats that were administered a high concentration (11.9% v/v) of alcohol during early neonatal brain development. In general, ECC procedures are sound diagnostic tools for detecting brain dysfunction across many psychological and biomedical settings.
Graphene Coatings for Biomedical Implants Ramakrishna Podila1,2, Thomas Moore3, Frank Alexis3, Apparao Rao1,4 1Department of Physics, Clemson University, 2Department of Pharmacology and Toxicology, East Carolina University, 3Department of Bioengineering, Clemson University, 4Center for Optical Materials Science and Engineering Technologies, Clemson University Graphene offers potential as a coating material for biomedical implants. In this study we demonstrate a method for coating nitinol alloys with nanometer thick layers of graphene and determine how graphene may influence implant response.
Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction Jitka A.I. Virag1, Robert M. Lust1 1Department of Physiology, Brody School of Medicine, East Carolina University Numerous genetic manipulations and/or intramyocardial injections of genes, proteins, cells, and/or biomaterials are superimposed upon the dimension of time in studies of acute ischemia/ reperfusion injury and chronic remodeling in mice. This video illustrates the microsurgical procedures for ischemia/reperfusion, permanent coronary artery ligation, and intramyocardial injection studies.