Philip Morris International: PMI 1 article published in JoVE Biology High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC) Diego Marescotti1, Ignacio Gonzalez Suarez1, Stefano Acali1, Stephanie Johne1, Alexandra Laurent1, Stefan Frentzel1, Julia Hoeng1, Manuel C. Peitsch1 1Biological System Research (BSR), Philip Morris International R&D The objective of the study was to assess the biological impact of 15 cigarette smoke constituents using a combination of an impedance-based real time cell analyzer and a high-content screening (HCS)-based platform for toxicological assessment in vitro. This study provides information on effective doses, toxicity and modes of action of the tested compounds.
