Pontifical Catholic University of Parana 1 article published in JoVE Cancer Research Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection Safwan Alomari1, Jayanidhi Kedda1, Adarsha P. Malla2,3, Victor Pacis1, Pavlos Anastasiadis2,3, Su Xu4, Emylee McFarland2,3, Lilia Sukhon1, Bruno Gallo5, Jordina Rincon-Torroella1, Netanel Ben-Shalom1, Heather M. Ames3,6, Henry Brem1,7, Graeme F. Woodworth2,3, Betty Tyler1 1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Neurosurgery, University of Maryland School of Medicine, 3Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, 4Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 5Pontifical Catholic University of Parana, 6Department of Pathology, University of Maryland School of Medicine, 7Departments of Ophthalmology, Oncology and Biomedical Engineering, Johns Hopkins University School of Medicine The present protocol describes a standardized resection of brain tumors in rodents through a minimally invasive approach with an integrated tissue preservation system. This technique has implications for accurately mirroring the standard of care in rodent and other animal models.
