Scinogy 1 article published in JoVE Bioengineering Automated Counterflow Centrifugal System for Small-Scale Cell Processing Anqi Li1,2, Stephen Wilson3, Ian Fitzpatrick3, Mehri Barabadi1,2, Siow Teng Chan1, Mirja Krause1,2, Gina Diamanta Kusuma1,2, David James3, Rebecca Lim1,2,4 1The Ritchie Centre, Hudson Institute of Medical Research, 2Department of Obstetrics and Gynaecology, Monash University, 3Scinogy, 4Australian Regenerative Medicine Institute, Monash University Automation is key to upscaling and cost management in cell manufacturing. This manuscript describes the use of a counterflow centrifugal cell processing device for automating the buffer exchange and cell concentration steps for small-scale bioprocessing.