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Neuroscience

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Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice

Article DOI: 10.3791/2618-v • 07:03 min • August 24th, 2011
August 24th, 2011 •
1,2,3, 2, 1, 2, 4, 4
1Department of Neurology, University of Connecticut Health Center, 2Department of Neurology, School of Medicine, University of Pennsylvania, 3Department of Neurosurgery, Hartford Hospital, 4Department of Neurosurgery, School of Medicine, University of Pennsylvania

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The autologous blood injection model of intracerebral hemorrhage in mice described in this protocol uses the double injection technique to minimize risk of blood reflux up the needle track, no anticoagulants in the pumping system, and eliminates all dead space and expandable tubing in the system.

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Autologous Blood Injection Spontaneous Intracerebral Hemorrhage Mice Model Pathophysiology Of Injury Intracerebral Hemorrhage Reproducible Animal Model Effective Therapy Stereotaxic Injection Arterial Blood Basal Ganglia Spontaneous Hypertensive Hemorrhage Neurobehavioral Deficits Potential Therapeutic Agents Double Injection Technique Blood Reflux Anticoagulants Dead Space Expandable Tubing
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