The modified Landis technique enables paired measurement of the hydraulic conductivity of individual microvessels in the mesentery of normal and genetically modified rats under control and test conditions using microperfusion techniques. It provides a convenient method to evaluate mechanisms that regulate microvessel permeability and transvascular exchange under physiological conditions.
Curry, F. E., Clark, J. F., Adamson, R. H. Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery. J. Vis. Exp. (103), e53210, doi:10.3791/53210 (2015).