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High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
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High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)

Article DOI: 10.3791/53987-v • 11:38 min • May 10th, 2016
May 10th, 2016 •
1, 1, 1, 1, 1, 1, 1, 1
1Biological System Research (BSR), Philip Morris International R&D

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The objective of the study was to assess the biological impact of 15 cigarette smoke constituents using a combination of an impedance-based real time cell analyzer and a high-content screening (HCS)-based platform for toxicological assessment in vitro. This study provides information on effective doses, toxicity and modes of action of the tested compounds.

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High Content Screening Analysis Toxicological Effects Harmful And Potentially Harmful Constituents (HPHC) Impedance-Based Real Time Cell Analyzer High Content Screening-Based Platform Effective Doses Toxicity Biological Effects Tox Profile Cytotoxicity Genotoxicity Cellular Stress Responses Biochemical Parameters Morphological Parameters Cell Types Cell Culture Models Compound Assessment Protocol Normal Human Bronchial Epithelial Cells (NHBE Cells) Impedance Measurements Plate Background
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