An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Hannah L. Bolt; Paul W. Denny; Steven L. Cobb

doi:10.3791/54750

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Un metodo efficiente per la sintesi di peptoids con monomeri misto Lisina-tipo / Arginina-tipo e valutazione della loro attività anti-Leishmania

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

JoVE Journal
Biochimica

This content is Free Access.

JoVE Journal Biochimica

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Un metodo efficiente per la sintesi di peptoids con monomeri misto Lisina-tipo / Arginina-tipo e valutazione della loro attività anti-Leishmania

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11,960 Views

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12:02 min

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November 02, 2016

DOI:

10.3791/54750-v

DOI:

10.3791/54750-v

•

12:02 min

November 02, 2016

•

2 Views

Hannah L. Bolt¹, Paul W. Denny², Steven L. Cobb¹

¹Department of Chemistry,Durham University, ²School of Medicine, Pharmacy and Health,Durham University

Trascrizione

Summary

A protocol to synthesize peptoids with mixed cationic functionality in the same sequence is presented (lysine- and arginine-type monomers). Subsequent testing of these compounds against Leishmania mexicana, the protozoan parasites that cause cutaneous leishmaniasis, is also described.