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Retinoblastoma Protein: Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1a protein, the Sv40 t antigen, and the human papilloma virus E7 protein.

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

1School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, 2Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 3Department of Obstetrics and Gynecology, School of Medicine, Texas Tech University Health Sciences Center

JoVE 59460


 Cancer Research

A Protein Preparation Method for the High-throughput Identification of Proteins Interacting with a Nuclear Cofactor Using LC-MS/MS Analysis

1Graduate School of Frontier Biosciences, Osaka University, 2Department of Biotechnology and Genetic Engineering, Jahangirnagar University, 3Division of Cell Regeneration and Transplantation, School of Medicine, Nihon University, 4Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 5Graduate School of Life and Medical Sciences, Doshisha University

JoVE 55077


 Biochemistry

Negative Regulator Molecules

JoVE 10764

Several proteins negatively regulate the cell cycle to prevent replication from occurring before cells are ready. During G1, if a cell’s DNA is damaged, the protein p53 recruits enzymes to repair the DNA before the cell transitions to S phase. p53 also stimulates the production of the Cdk inhibitor, p21, which binds to Cdk/cyclin complexes, inhibiting their activity and arresting the…


 Core: Cell Cycle and Division

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