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RNA-Induced Silencing Complex: A multicomponent, ribonucleoprotein complex comprised of one of the family of Argonaute proteins and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. Risc cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, Small interfering), miRNA (Microrna), or piRNA (Piwi-interacting rna).

RNAi in C. elegans

JoVE 5105

RNA interference (RNAi) is a widely used technique in which double stranded RNA is exogenously introduced into an organism, causing knockdown of a target gene. In the nematode, C. elegans, RNAi is particularly easy and effective because it can be delivered simply by feeding the worms bacteria that express double stranded RNA (dsRNA) that is complementary to a gene of interest. First,…


 Biology I

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