Achucarro Basque Center for Neuroscience 1 article published in JoVE Neuroscience Histological Examination of Mitochondrial Morphology in a Parkinson's Disease Model Dalila Ciceri*1, Lierni Gregorio-Zabala*1, Xabier Llama-Pino1, Begüm Kurt1, Jon Olano-Bringas1, Patricia Villegas-Zafra1, Nora Bengoa-Vergniory1,2,3,4 1Achucarro Basque Center for Neuroscience, 2Department of Neuroscience, University of the Basque Country (UPV/EHU), 3Ikerbasque - Basque Foundation for Science, 4Oxford Parkinson’s Disease Centre and Department of Physiology, Anatomy and Genetics, University of Oxford This study presents a method to analyze the morphology of mitochondria based on immunostaining and image analysis in mouse brain tissue in situ. It also describes how this allows one to detect changes in mitochondrial morphology induced by protein aggregation in Parkinson's disease models.
