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Immunology and Infection

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HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL

Article DOI: 10.3791/2801-v • 07:19 min • April 11th, 2011
April 11th, 2011 •
1,2, 3,4, 3,4
1Immunology Graduate Program, Johns Hopkins University, 2Department of Internal Medicine, Far-Eastern Memorial Hospital, 3Department of Pathology, Johns Hopkins University, 4Institute of Cell Engineering, Johns Hopkins University

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요약
Automatic Translation

A new DC independent method for induction and expansion of antigen-specific T cells is described. HLA A2-Ig based artificial Antigen Presenting Cells (aAPC) are loaded with HLA-A2 restricted peptides to efficiently expand CTL of diverse antigen specificity. This technology holds great potential for CTL-based adoptive immunotherapy.

Tags

HLA-Ig Artificial Antigen Presenting Cells Ex Vivo Expansion Human CTL Effector Function Immune Microenvironment Autologous Antigen Presenting Cells Tolerize Anergize Adoptive Immunotherapy Cancer Virus Infections CMV-specific CTL Immunocompromised Allogeneic Bone Marrow Transplant Patients Anti-CMV Immunity Melanoma Cost And Technical Limitations Autologous DC Leukocytes
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