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1单侧损毁6 - 羟基多巴胺帕金森病小鼠模型的发展

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Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson’s Disease

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1单侧损毁6 - 羟基多巴胺帕金森病小鼠模型的发展

DOI:

•

10:09 min

•

February 14, 2012

•

Sherri L. Thiele, Ruth Warre, Joanne E. Nash

¹Centre for Neurobiology of Stress, Dept Biological Sciences,University of Toronto at Scarborough

Chapters

00:05Title
01:00Setting up the Surgical Apparatus
04:20Unilateral 6-OHDA Lesion Surgery
08:46Representative Results for the Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson’s Disease
09:40Conclusion

Summary

자동 번역

一个6-OHDA单侧病变，内侧前脑束对小鼠进行的协议说明。该方法具有低死亡率与89％的幸存的动物> 95％的损失纹状体多巴胺和90.63率（13.3％）±-4.02％ipsiversive旋转对病灶侧的偏见。

Tags

Unilaterally-lesioned 6-OHDA Mouse Model Parkinson’s Disease Basal Ganglia Circuitry Parkinsonian Symptoms Cortico-striatal Synapses Striatum Pathological Abnormalities Nigro-striatal Pathway Bacterial Artificial Chromosome (BAC) Mice Green Fluorescent Proteins Direct Pathway Indirect Pathway Synaptic Plasticity Juvenile Mice Acute Models Of Parkinsonism

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