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基于逆电子需求函数-alder 反应的隐形放射免疫治疗

Article DOI: 10.3791/59041-v • 09:44 min • January 29th, 2019
January 29th, 2019 •
1,2, 1,2,3, 1,2,3,4
1Department of Chemistry, Hunter College of the City University of New York, 2Ph.D. Program in Chemistry, Graduate Center of the City University of New York, 3Department of Radiology, Memorial Sloan Kettering Cancer Center, 4Department of Radiology, Weill Cornell Medical College

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该协议描述了反式环磷 (tco) 修饰抗体和177个lu-tazine (tz) 辐射寡核苷酸的合成和表征, 用于预定目标放射治疗 (prit)。此外, 它还详细介绍了这两种结构在结直肠癌小鼠模型中的应用, 用于体内生物分布和纵向治疗研究。

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化学 第143期 放射免疫治疗 预定源放射免疫治疗 预靶向 反电子需求狄埃尔德反应 四氮素,反环化 hua33 a33 抗原 黄体-177
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