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Cancer Research

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Oprichting van zebravispatiënt-afgeleide xenografts van alvleesklierkanker voor chemosensitiviteitstests

Article DOI: 10.3791/63744-v • 06:59 min • May 12th, 2023
May 12th, 2023 •
1, 2, 1, 2, 1
1Department of Biology, University of Pisa, 2General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa

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Preklinische modellen zijn bedoeld om de kennis van kankerbiologie te vergroten en de werkzaamheid van de behandeling te voorspellen. Dit artikel beschrijft de generatie van op zebravissen gebaseerde patiënt-afgeleide xenografts (zPDXs) met tumorweefselfragmenten. De zPDXs werden behandeld met chemotherapie, waarvan het therapeutische effect werd beoordeeld in termen van celapoptose van het getransplanteerde weefsel.

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Cancer Research zebravis avatar preklinisch model co-klinische studie tumortransplantatie chemosensitiviteit whole-mount immunofluorescentie
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