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Cancer Research

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JoVE Journal Cancer Research
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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Journal (Cancer Research)
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Evaluation of the Cell Invasion and Migration Process: A Comparison of the Video Microscope-based Scratch Wound Assay and the Boyden Chamber Assay
Journal (Cancer Research)
Evaluation of the Cell Invasion and Migration Process: A Comparison of the Video Microscope-based Scratch Wound Assay and the Boyden Chamber Assay
 

High-Throughput Screening of CAR T-Cell Constructs for Enhanced Cytotoxicity and Immunologic Memory (Video) | JoVE

Evaluating Quantitative Tumor Cell Killing by CAR-Expressing Jurkat Cells

Article DOI: 10.3791/65560-v • 01:44 min • October 27th, 2023
October 27th, 2023 •
*1,2,3, *1, 4, 2, 1, 4,5,6, 1,2,3
1Department of Radiation Oncology, University of Kansas Cancer Center, 2Department of Cancer Biology, University of Kansas Cancer Center, 3BioEngineering Program, University of Kansas, 4Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 5University of Kansas Cancer Center, 6Kansas Institute for Precision Medicine, University of Kansas Medical Center
* These authors contributed equally

Tags

Rapid In Vitro Cytotoxicity Evaluation Jurkat Chimeric Antigen Receptor Fluorescent Imaging CAR T Cells Targeting Domain Single Chain Variable Fragment Intra-chain Linker Hinge Domain Transmembrane Domain Costimulatory Domain CAR Construct CAR-mediated Killing CAR-T Cells Time-consuming Process Expensive Process Testing Constructs Time And Material Investment Platform Hinge-optimized CAR Constructs Jurkat Cells Lentivirus Uptake CAR Transduction Fluorescent Imager Cytolysis PBMC-derived T Cells
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