The Sixth Affiliated Hospital of Sun Yat-sun University 1 article published in JoVE Behavior Effects of Surgical Masks on Cardiopulmonary Function in Healthy Subjects Mei Li*1,2,4, Haining Ou*1,2,3,4, Qinyi Li1,2,4, Junjie Liang1,2,4, Weihao Liao1,2,4, Shijuan Lang1,2,4, Hongxin Chen1,2,4, Yafei Wang5, Kun Tang1,2,4, Qiang Lin*1,2,3,4, Yuxin Zheng*1,2,4 1Department of Rehabilitation Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, 2The Rehabilitation Medicine Lab of Guangzhou Medical University, 3Guangzhou Key Laboratory of Enhanced Recovery after Abdominal Surgery, The Fifth Affiliated Hospital of Guangzhou Medical University, 4Department of Rehabilitation Therapy, Guangzhou Medical University, 5Department of Rehabilitation Medicine, The Sixth Affiliated Hospital of Sun Yat-sun University We study the effect of surgical masks on cardiopulmonary function based on a cardiopulmonary exercise test (CPET). This study shows that surgical masks reduce cardiopulmonary exercise capacity and ventilation in healthy young subjects and wearing masks might affect aerobic exercise capacity more in female subjects than in male subjects.