Richmond VA Medical Center 1 article published in JoVE Medicine Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft Rishav Aggarwal1, Annie Shao1, Koray N. Potel2, Laura Hocum Stone1, Cory Swingen1, Christin Wright1, Edward O. McFalls3, Tammy A. Butterick4,5, Rosemary F. Kelly1 1Department of Surgery, University of Minnesota, 2 This study presents a surgical porcine model of chronic myocardial ischemia due to progressive coronary artery stenosis, resulting in impaired cardiac function without infarction. Following ischemia, animals undergo off-pump coronary artery bypass graft with epicardial placement of stem cells-derived exosomes-laden collagen patch. This adjunctive therapy improves myocardial function and recovery.