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Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

Article DOI: 10.3791/63566-v • 04:45 min • June 2nd, 2022
June 2nd, 2022 •
*1,2,5, *1,2,6, 1,3,4, 1,3, 1,2,4,5,6
1Laboratório de Imunofarmacologia, Fundação Oswaldo Cruz, FIOCRUZ, 2Laboratório de Imunofarmacologia, Departamento de Bioquímica, Instituto Biomédico, Universidade Federal do Estado do Rio de Janeiro, 3Programa de Pós-Graduação em Biologia Celular e Molecular, Instituto Oswaldo Cruz, FIOCRUZ, 4Programa de Pós-Graduação em Biologia Molecular e Celular, Universidade Federal do Estado do Rio de Janeiro, 5Programa de Pós-Graduação em Ciências e Biotecnologia, Universidade Federal Fluminense, 6Programa de Pós-Graduação em Neurociências, Universidade Federal Fluminense
* These authors contributed equally

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Resumo
Automatic Translation

The present protocol describes a lung injury model in mice using oleic acid to mimic acute respiratory distress syndrome (ARDS). This model increases the inflammatory mediators on edema and decreases lung compliance. Oleic acid is used in the salt form (oleate) since this physiological form avoids the risk of embolism.

Tags

Mouse Model Oleic Acid-induced Acute Respiratory Distress Syndrome ARDS Pollutant Exposure Cigarette Smoke Infectious Agents Fatty Acids Animal Models Pathomechanism Limitations Oleic Acid (OA) Harmful Effects On The Lung Lung Injury Emboli Disrupting Tissue Altering PH Impairing Edema Clearance Endothelial Injury Alveolar Permeability Inflammation Membrane Hyaline Formation Cell Death Injection Of OA (in Salt Form) Physiological Form Of OA At PH 7
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