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الفصل 7

اصلاح واعادة تركيب الحمض النووى الريبوزى منقوص الهيدروجين

نظرة عامة على اصلاح الحمض النووى الريبوزى منزوع الاكسجين
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand…
الاصلاح بإستئصال قاعدة
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing…
الاصلاح بإستئصال عدد من القواعد
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining…
ترميم استئصال النكليوتيد
Exposure to mutagens can damage DNA and result in bulky lesions that distort the double-helix structure or impede proper transcription. Damaged DNA…
بوليميراز توليف الحمض النووى الريبوزى منزوع الاكسجين
Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a…
اصلاح التلف مزدوج الشريط
The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves…
التلف الحادث فى الحمض النووى الريوزى يمكن ان يعطل دورة الخلية
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical…
اعادة التركيب المتماثل
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One…
اعادة تشغيل شوكة الاستنساخ المتوقفة
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the…
التحول الجينى
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the…
نظرة عامة على انتقال واعادة تركيب
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role…
الجين القافز فقط على الحمض النووى الريبوزى منزوع الاكسجين
DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism.…
الفيروس المرتد
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on…
القافزات الارتدادية للمتكررات الطويلة الطرفية
LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less…
القافزات الارتدادية لغير المتكررات الطويلة الطرفية
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and…
اعادة تركيب محدد بالمواقع المحافظة و اختلاف الاطوار
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic…
القوة الذرية المجهري التحقيقات من الحمض النووي الآفة الاعتراف في إصلاح ختان النوكليوتيدات
AFM imaging is a powerful technique for the study of protein-DNA interactions. This single molecule method allows the simultaneous resolution of…
المراقبة في الوقت الحقيقي من رد تبادل حبلا الحمض النووي توسط Rad51
The DNA strand exchange reaction mediated by Rad51 is a critical step of homologous recombination. In this reaction, Rad51 forms a nucleoprotein…
الجيش النيبالي الجديد الجيل التالي التسلسل وخط أنابيب المعلوماتية الحيوية لتحديد خط التعبير-1s في مستوي محدد الموضع
Long INterspersed Elements-1 (LINEs/L1s) are repetitive elements that can copy and randomly insert in the genome resulting in genomic instability and…

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