8.6: 丙酮酸氧化
糖酵解后,带电荷的丙酮酸分子通过主动转运进入线粒体,进行三种酶促反应。这些反应确保丙酮酸盐可以进入下一个代谢途径,这样储存在丙酮酸分子中的能量就可以被细胞利用。
首先,丙酮酸脱氢酶从丙酮酸中除去羧基,并将其释放为二氧化碳。剥离的分子然后被氧化并释放电子,然后被NAD+吸收产生NADH,形成乙酸盐。
最后,辅酶A是从B族维生素中提取的含硫化合物,通过其硫原子附着在乙酸盐上,生成乙酰辅酶A或乙酰辅酶A。乙酰辅酶A然后进入柠檬酸循环,在那里它将被进一步氧化。
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糖酵解后,带电荷的丙酮酸分子通过主动转运进入线粒体,进行三种酶促反应。这些反应确保丙酮酸盐可以进入下一个代谢途径,这样储存在丙酮酸分子中的能量就可以被细胞利用。
首先,丙酮酸脱氢酶从丙酮酸中除去羧基,并将其释放为二氧化碳。剥离的分子然后被氧化并释放电子,然后被NAD+吸收产生NADH,形成乙酸盐。
最后,辅酶A是从B族维生素中提取的含硫化合物,通过其硫原子附着在乙酸盐上,生成乙酰辅酶A或乙酰辅酶A。乙酰辅酶A然后进入柠檬酸循环,在那里它将被进一步氧化。
Schell, John C, and Jared Rutter. “The Long and Winding Road to the Mitochondrial Pyruvate Carrier.” Cancer & Metabolism 1 (January 23, 2013): 6. [Source]
McCommis, Kyle S., and Brian N. Finck. “Mitochondrial Pyruvate Transport: A Historical Perspective and Future Research Directions.” The Biochemical Journal 466, no. 3 (March 15, 2015): 443–54. [Source]
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