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Behavior

Farelerde Tekrarlanan, Kompulsif gibi Davranışlarının Testler gibi mermer Burying ve Nestlet Parçalama

doi: 10.3791/50978 Published: December 24, 2013

Materials

Name Company Catalog Number Comments
Glass toy marbles local toy store N/A assorted styles, colors, clear, and opaque
Nestlets Ancare NES3600
N10 series mouse cage Ancare N10HT standard rodent cage with wire top
R20 series rat cage Ancare R20 standard rodent cage with wire top
Bed-o'Cobs The Andersons 8B standard rodent bulk bedding, 1/8 in

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References

  1. Chamberlain, S. R., Blackwell, A. D., Fineberg, N. A., Robbins, T. W., Sahakian, B. J. The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci. Biobehav. Rev. 29, 399-419 (2005).
  2. McGuire, J. F., Lewin, A. B., Horng, B., Murphy, T. K., Storch, E. A. The nature, assessment, and treatment of obsessive-compulsive disorder. Postgrad. Med. 124, 152-165 (2012).
  3. Fineberg, N. A., Brown, A., Reghunandanan, S., Pampaloni, I. Evidence-based pharmacotherapy of obsessive-compulsive disorder. Int. J. Neuropsychopharmacol. 15, 1173-1191 (2012).
  4. Dove, D., et al. Medications for adolescents and young adults with autism spectrum disorders: a systematic review. Pediatrics. 130, 717-726 (2012).
  5. Doyle, C. A., McDougle, C. J. Pharmacotherapy to control behavioral symptoms in children with autism. Expert Opin. Pharmacother. 13, 1615-1629 (2012).
  6. Albelda, N., Joel, D. Current animal models of obsessive compulsive disorder: an update. Neuroscience. 211, 83-106 (2012).
  7. Albelda, N., Joel, D. Animal models of obsessive-compulsive disorder: Exploring pharmacology and neural substrates. Neurosci. Biobehav. Rev. 36, 47-63 (2012).
  8. Wang, L., Simpson, H. B., Dulawa, S. C. Assessing the validity of current mouse genetic models of obsessive-compulsive disorder. Behav. Pharmacol. 20, 119-133 (2009).
  9. Joel, D. Current animal models of obsessive compulsive disorder: a critical review. Prog. Neuropsychopharmacol. Biol. Psychiatry. 30, 374-388 (2006).
  10. Witkin, J. M. Animal models of obsessive-compulsive disorder. Curr. Protoc. Neurosci. 30, 1-9 (2008).
  11. Deacon, R. M. Digging and marble burying in mice: simple methods for in vivo identification of biological impacts. Nat. Protoc. 1, 122-124 (2006).
  12. Moy, S. S., Nadler, J. J., Magnuson, T. R., Crawley, J. N. Mouse models of autism spectrum disorders: the challenge for behavioral genetics. Am. J. Med. Genet. C Semin. Med. Genet. 142, 40-51 (2006).
  13. Crawley, J. N. Mouse behavioral assays relevant to the symptoms of autism. Brain Pathol. 17, 448-459 (2007).
  14. Silverman, J. L., Yang, M., Lord, C., Crawley, J. N. Behavioural phenotyping assays for mouse models of autism. Nat. Rev. Neurosci. 11, 490-502 (2010).
  15. Angoa-Perez, M., et al. Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity. J. Neurochem. 121, 974-984 (2012).
  16. Kane, M. J., et al. Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism. PLoS One. 7, (2012).
  17. Deacon, R. M. Assessing nest building in mice. Nat. Protoc. 1, 1117-1119 (2006).
  18. Thomas, D. M., Angoa Perez,, Francescutti-Verbeem, D. M., Shah, M. M., Kuhn, D. M. The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum. J. Neurochem. 115, 595-605 (2010).
  19. Gyertyan, I. Analysis of the marble burying response: marbles serve to measure digging rather than evoke burying. Behav. Pharmacol. 6, 24-31 (1995).
  20. Thomas, A., et al. Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety. Psychopharmacology. 204, 361-373 (2009).
  21. Hayashi, E., Kuratani, K., Kinoshita, M., Hara, H. Pharmacologically distinctive behaviors other than burying marbles during the marble burying test in mice. Pharmacology. 86, 293-296 (2010).
Farelerde Tekrarlanan, Kompulsif gibi Davranışlarının Testler gibi mermer Burying ve Nestlet Parçalama
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Cite this Article

Angoa-Pérez, M., Kane, M. J., Briggs, D. I., Francescutti, D. M., Kuhn, D. M. Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice. J. Vis. Exp. (82), e50978, doi:10.3791/50978 (2013).More

Angoa-Pérez, M., Kane, M. J., Briggs, D. I., Francescutti, D. M., Kuhn, D. M. Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice. J. Vis. Exp. (82), e50978, doi:10.3791/50978 (2013).

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