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Capturing Oral Submucous Fibrosis Tissue Samples for Spatial-Omics Analysis

Article DOI: 10.3791/200508-v • 02:14 min • August 11th, 2023
August 11th, 2023 •
1,2, 3, 1,2, 1,2
1Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, 2Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences (2019RU034), 3Central Laboratory, Peking University School and Hospital of Stomatology

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Isolamento Cellule Informazioni morfologiche Informazioni spaziali Campioni di fibrosi sottomucosa orale Microdissezione a cattura laser Disturbo potenzialmente maligno Atrofia Epitelio Fibrosi Lamina propria Sottomucosa Vetrini istopatologici Displasia epiteliale Fibroblasti senescenti Trasformazione maligna Meccanismi molecolari Eterogeneità Carcinoma orale a cellule squamose Meccanismi molecolari specifici Vetrini di tessuto inclusi in paraffina fissati in formalina Microscopio Displastica su microscala Tessuto Tessuto epiteliale atrofico Tessuto subepiteliale fibrotico Sequenziamento del genoma Sequenziamento del trascrittoma Dati genomici Dati trascrittomici
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