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Journal / Immunology and Infection / Saf Hematopoetik kök / progenitör hücrelerin DNA…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Saf Hematopoetik kök / progenitör hücrelerin DNA mutasyonları belirlenmesi
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Saf Hematopoetik kök / progenitör hücrelerin DNA mutasyonları belirlenmesi

Article DOI: 10.3791/50752-v • 11:06 min • February 24th, 2014
February 24th, 2014 •
1, 1,2, 1, 3, 4,5, 2, 2,5, 1,2,5
1Greehey Children's Cancer Research Institute, UT Health Science Center at San Antonio, 2Department of Cellular and Structural Biology, UT Health Science Center at San Antonio, 3Department of Pathology, UT Health Science Center at San Antonio, 4Department of Microbiology, UT Health Science Center at San Antonio, 5Cancer Therapy and Research Center, UT Health Science Center at San Antonio

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Burada LacI transgenik fare modeli kullanılarak arıtılmış, hematopoietik hücrelerin az sayıda için bir in vivo deneyini tarif mutagenez. LacI gen DNA mutantlarının sıklığı, yer ve tip kendiliğinden ortaya çıkan veya Genotoksinlerin maruz kaldıktan sonra belirlemek için izole edilebilir.

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Enfeksiyon Sayı 84, hematopoetik kök / progenitör hücreler, DNA mutasyonlar
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