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Amide Réaction de couplage pour la synthèse de ligands à base de bispyridine et leur complexation Platinum comme dinucléaires agents anticancéreux
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Amide Réaction de couplage pour la synthèse de ligands à base de bispyridine et leur complexation Platinum comme dinucléaires agents anticancéreux

Article DOI: 10.3791/51740-v • 07:20 min • May 28th, 2014
May 28th, 2014 •
1, 2, 3, 4, 1
1Faculty of Pharmacy, The University of Sydney, 2School of Science and Health, University of Western Sydney, 3Division of Chemistry and Environmental Science, School of Science and the Environment, Manchester Metropolitan University, 4Nature Publishing Group

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Ce protocole décrit l'utilisation de réactions de couplage de l'amide d'acide isonicotinique et diaminoalcanes pour former ligands pontants appropriés pour une utilisation dans la synthèse de complexes de platine polynucléaires, qui combinent les aspects des médicaments anticancéreux et BBR3464 picoplatin.

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Chimie Numéro 87 BBR3464 picoplatin bispyridine couplage d'amide la synthèse inorganique cancer
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