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JoVE Journal Cancer Research
Oprichting en karakterisering van drie Afatinib-resistente Long adenocarcinoom PC-9 cellijnen ontwikkeld met toenemende doses van Afatinib
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Oprichting en karakterisering van drie Afatinib-resistente Long adenocarcinoom PC-9 cellijnen ontwikkeld met toenemende doses van Afatinib

Article DOI: 10.3791/59473-v • 09:38 min • June 26th, 2019
June 26th, 2019 •
1, 1, 2, 1, 3
1Advanced Cancer Translational Research Institute, Showa University, 2Division of Breast Surgical Oncology, Department of Surgery, Showa University School of Medicine, 3Division of Allergology and Respiratory Medicine, Department of Medicine, Showa University School of Medicine

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Een methode voor het vaststellen van afatinib-resistentie cellijnen van Long adenocarcinoom PC-9 cellen werd ontwikkeld, en resistente cellen werden gekarakteriseerd. De resistente cellen kunnen worden gebruikt voor het onderzoeken van epidermale groeifactor receptor tyrosine kinase remmer-resistentiemechanismen, toepasbaar voor patiënten met niet-kleincellige longkanker.

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Kankeronderzoek probleem 148 stapsgewijze dosisescalatie resistentie tegen geneesmiddelen EGFR-activerende mutaties EGFR-TKI afatinib longkanker
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